- E-SWAT (Arcade)
- E.T. The Extra-Terrestrial and the Cosmic Garden (GBC)
- E.T. The Extra-Terrestrial: Digital Companion (GBC)
- E.T. The Extra-Terrestrial: Escape from Planet Earth (GBC)
- E.X. Troopers (3DS)
- EA Playground (DS)
- EA Playground (Wii)
- EA Sports Active (Wii)
- EA Sports Active 2 Personal Trainer (Wii)
- EA Sports FC 24 (Switch)
- EA Sports FC 25 (Switch)
- EA SPORTS FC 26 (Switch 2)
- EA SPORTS Madden NFL 26 (Switch 2)
- Eagle Island (Switch eShop)
- Eagle Simulator - Bird Zoo Park Flight Sky Pilot Driving (Switch eShop)
- EAGLETALON vs. HORDE OF THE FLIES (Switch eShop)
- Early Learning Games for Kids, Toddlers & Babies (Switch eShop)
- Earth Atlantis (Switch eShop)
- Earth Defense Force 2017 (Switch eShop)
- Earth Defense Force 2: Invaders from Planet Space (Switch eShop)
- Earth Defense Force: World Brothers (Switch eShop)
- Earth Defense Force: World Brothers 2 (Switch eShop)
- Earth Light (SNES)
- Earth Marines (Switch eShop)
- Earth Wars (Switch eShop)
- Earthblade (Switch eShop)
- EarthBound (SNES)
- EarthBound Beginnings (NES)
- Earthen Dragon (Switch eShop)
- Earthfall: Alien Horde (Switch eShop)
- Earthion (MD)
- Earthlock (Switch eShop)
- Earthlock: Festival of Magic (Wii U eShop)
- EarthNight (Switch eShop)
- Earthshine (Switch eShop)
- Earthworm Jim (DSiWare)
- Earthworm Jim (GB)
- Earthworm Jim (MD)
- Earthworm Jim (SNES)
- Earthworm Jim 2 (MD)
- Earthworm Jim 2 (SNES)
- Earthworm Jim 3D (N64)
- Earthworm Jim: Menace 2 the Galaxy (GBC)
- Earthworms (Switch eShop)
- EarthX (Switch eShop)
- Easter Bunny: Bubble Shooter (Switch eShop)
- Easter Eggztravaganza (DSiWare)
- Eastern Euro Truck Simulator: Real Offroad Car Driving Game Sim 4x4 Mud (Switch eShop)
- Eastern Exorcist (Switch eShop)
- Eastward (Switch eShop)
- Eastward: Octopia (Switch eShop)
- Easy Come Easy Golf (Switch eShop)
- Easy Cute Clean Up Lesson (Switch eShop)
- Easy Dice for RPG/Tabletop (Switch eShop)
- Easy Flight Simulator (Switch eShop)
- Easy Japanesey (Switch eShop)
- Easy Japanesey 2 (Switch eShop)
- Easy Japanesey 3 (Switch eShop)
- EASY LEARNING CLASSICAL MUSIC (Switch eShop)
- Easy Piano (DS)
- Easy Red 2 (Switch eShop)
- Eat Beat Deadspike-San (Switch eShop)
- Eat your letters (Switch eShop)
- Eat! Fat! FIGHT! (WiiWare)
- Eba & Egg: A Hatch Trip (Wii U eShop)
- Ebenezer and the Invisible World (Switch eShop)
- Ecchi Blast Vol. 1 (Switch eShop)
- Ecchi Fever (Switch eShop)
- Ecchi Memories (Switch eShop)
- Ecchi Oppai (Switch eShop)
- Ecchi Paradise (Switch eShop)
- Ecchi Secrets (Switch eShop)
- Ecchi Time (Switch eShop)
- Ecchi Uncover (Switch eShop)
- Ecco Jr. (MD)
- Ecco The Dolphin (MD)
- Ecco: The Tides of Time (MD)
- Echo Generation: Midnight Edition (Switch eShop)
- EchoBlade (Switch eShop)
- Echoes (Switch eShop)
- Echoes of the Plum Grove (Switch eShop)
- Echolocaution (Switch eShop)
- Ecks vs. Sever (GBA)
- Eclipse: Edge of Light (Switch eShop)
- Eco Creatures: Save the Forest (DS)
- Eco Fighters (Arcade)
- Eco Shooter: Plant 530 (WiiWare)
- EcoGnomix (Switch eShop)
- EcoMahjong (Switch eShop)
- eCrossminton (Switch eShop)
- EctoPlaza (Wii U eShop)
- ECW Hardcore Revolution (GBC)
- ECW Hardcore Revolution (N64)
- Ed, Edd n Eddy: Scam of the Century (DS)
- Ed, Edd n Eddy: The Mis-Edventures (GCN)
- Eden Genesis (Switch eShop)
- Eden Survivors (Switch eShop)
- Eden's Last Sunrise (Switch eShop)
- Edgar - Bokbok in Boulzac (Switch eShop)
- EDGE (3DS eShop)
- EDGE (Wii U eShop)
- Edge of Eternity - Cloud Version (Switch)
- Edge of Reality (Switch eShop)
- Edge of Sanity (Switch eShop)
- Editor's Hell - Newspaper Story (Switch eShop)
- Edna & Harvey: Harvey's New Eyes (Switch eShop)
- Edna & Harvey: Harvey's New Eyes (Switch eShop)
- Edna & Harvey: The Breakout - Anniversary Edition (Switch eShop)
- Edo Bunka Rekishi Kentei (DS)
- Eduardo the Samurai Toaster (WiiWare)
- Educational and Learning Bundle - 5 in 1 (Switch eShop)
- Educational Games For Kids (Switch eShop)
- Educational Pack of Kids Games (Wii U eShop)
- Eek! the Cat (SNES)
- Eekeemoo - Splinters of the Dark Shard (Switch eShop)
- Effie (Switch eShop)
- Egg Mania (GBA)
- Egg Mania: Eggstreme Madness (GCN)
- Egg Monster Hero (DS)
- Egg Over It: Fall Flat from the Top (Switch eShop)
- Egg Runner (Switch eShop)
- Egg Up (Switch eShop)
- EGGCONSOLE Aqua Polis SOS MSX (Switch eShop)
- EGGCONSOLE Arctic PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Arguice no Tsubasa PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Babylon PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Burai: Jokan PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Carmine 88 PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Crimson PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Dinosaur PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Dragon Slayer IV DRASLEFAMILY MSX2 (Switch eShop)
- EGGCONSOLE Dragon Slayer: The Legend of Heroes II PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Dragon Slayer: The Legend of Heroes PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Guardic MSX (Switch eShop)
- EGGCONSOLE Gulkave MSX (Switch eShop)
- EGGCONSOLE How Many Robot PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Hydlide II PC-8801 (Switch eShop)
- EGGCONSOLE Hydlide MSX (Switch eShop)
- EGGCONSOLE Hydlide PC-8801 (Switch eShop)
- EGGCONSOLE Hydlide3 PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Marchen Veil PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Murder Club PC-8801 (Switch eShop)
- EGGCONSOLE Popful Mail PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Pyramid Warp MSX (Switch eShop)
- EGGCONSOLE Relics PC-8801 (Switch eShop)
- EGGCONSOLE Riglas PC-8801 (Switch eShop)
- EGGCONSOLE Seilane PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Shin Maou Golvellius MSX2 (Switch eShop)
- EGGCONSOLE Silpheed PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Silver Ghost PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Sorcerian PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Star Cruiser PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Star Trader PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Super Zenon Gamma 5 PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Templo Del Sol: Asteka II PC-8801 (Switch eShop)
- EGGCONSOLE The Legend of Heroes Saga PC-8801 (Switch eShop)
- EGGCONSOLE The Scheme PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Thexder PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Topple Zip PC-8801 (Switch eShop)
- EGGCONSOLE Tritorn PC-8801 (Switch eShop)
- EGGCONSOLE Undeadline MSX2 (Switch eShop)
- EGGCONSOLE Wanderers from Ys MSX2 (Switch eShop)
- EGGCONSOLE Wanderers From Ys PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Xak II PC-8801MKIISR (Switch eShop)
- EGGCONSOLE Xak PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Xanadu PC-8801 PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Xanadu Scenario II PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Yokai Tantei PC-8801 (Switch eShop)
- EGGCONSOLE Ys II MSX2 (Switch eShop)
- EGGCONSOLE Ys II PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Ys MSX2 (Switch eShop)
- EGGCONSOLE Ys PC-8801mkIISR (Switch eShop)
- EGGCONSOLE Zanac MSX (Switch eShop)
- Eggggg - The platform puker (Switch eShop)
- EGGLIA Rebirth (Switch eShop)
- Egglien (Switch eShop)
- Eggy Party (Switch eShop)
- Ego Protocol: Remastered (Switch eShop)
- Eigengrau (Switch eShop)
- Eight Dragons (Switch eShop)
- Eight-Minute Empire (Switch eShop)
- Eiko no Saint Andrews (N64)
- Ein's Sword (Switch eShop)
- Ein's Sword2 (Switch eShop)
- Ein's Sword3 (Switch eShop)
- Eisei Meijin VI (GCN)
- Eiyuden Chronicle: Hundred Heroes (Switch eShop)
- Eiyuden Chronicle: Rising (Switch eShop)
- EJ Puzzles: Hooked (DSiWare)
- Ekstase (Switch eShop)
- El Gancho (Switch eShop)
- El Hijo: A Wild West Tale (Switch eShop)
- El Panadero -The Baker- (Switch eShop)
- El Shaddai: Ascension of the Metatron HD Remaster (Switch eShop)
- El Silla - Arcade Edition (Wii U eShop)
- El Tigre: The Adventures of Manny Rivera (DS)
- Elasto Mania II (Switch eShop)
- Elasto Mania Remastered (Switch eShop)
- Elasto Mania Trilogy Pack (Switch eShop)
- Elden Ring: Tarnished Edition (Switch 2)
- Elden: Path of the Forgotten (Switch eShop)
- Elder Sister's Love Training (Switch eShop)
- Elder Story (Switch eShop)
- Elderand (Switch eShop)
- Eldest Souls (Switch eShop)
- Eldgear (Switch eShop)
- Eldrador Creatures (Switch eShop)
- Eldrador Creatures Shadowfall (Switch eShop)
- ELEA: Paradigm Shift (Switch eShop)
- Elebits (Wii)
- ElecHead (Switch eShop)
- Electrician Simulator (Switch eShop)
- Electro Ride: The Neon Racing (Switch eShop)
- Electronic Super Joy (Switch eShop)
- Electronic Super Joy (Wii U eShop)
- Electronic Super Joy 2 (Switch eShop)
- Electronic Super Joy: Groove City (Wii U eShop)
- Electronics Puzzle Lab (Switch eShop)
- Electronics Supermarket Simulator (Switch eShop)
- Electroplankton (DS)
- Electroplankton Beatnes (DSiWare)
- Electroplankton Hanenbow (DSiWare)
- Electroplankton Lumiloop (DSiWare)
- Electroplankton Luminarrow (DSiWare)
- Electroplankton Marine-Crystals (DSiWare)
- Electroplankton Nanocarp (DSiWare)
- Electroplankton Rec-Rec (DSiWare)
- Electroplankton Sun-Animalcule (DSiWare)
- Electroplankton Trapy (DSiWare)
- Electroplankton Varvoice (DSiWare)
- Eledees: The Adventures of Kai and Zero (DS)
- Element (Switch eShop)
- Elemental Cube (Switch eShop)
- Elemental Knights R (Switch eShop)
- Elemental Master (MD)
- Elemental Masters (DSiWare)
- Elemental Monster (DS)
- Elemental Princesses: Super Magical Quest (Switch eShop)
- Elemental War 2 (Switch eShop)
- Elementallis (Switch eShop)
- Elements (Switch)
- Elements of Destruction (DS)
- EleMetals: Death Metal Death Match! (Switch eShop)
- Elevator Action (Arcade)
- Elevator Action (GB)
- Elevator Action (NES)
- Elevator Action -Returns- S-Tribute (Switch eShop)
- Elevator Action EX (GBC)
- Elevator...to the Moon! Turbo Champion's Edition (Switch eShop)
- Elf Bowling 1 & 2 (DS)
- Eliminate Down (MD)
- Eliminator Boat Duel (NES)
- Elite (NES)
- Elite Beat Agents (DS)
- Elite Forces: Unit 77 (DS)
- Elite Forces: Unit 77 (DSiWare)
- Elite Soccer (GB)
- Elite Soldier Shooter (Switch eShop)
- Eliza (Switch eShop)
- Ellada Games RPG Bundle (Switch eShop)
- Ellen (Switch eShop)
- Elli (Switch eShop)
- Elliot (Switch eShop)
- Elliot Quest (3DS eShop)
- Elliot Quest (Switch eShop)
- Elliot Quest (Wii U eShop)
- Ellipsis (Switch eShop)
- Elminage DS Remix: Yami no Miko to Kamigami no Yubiwa (DS)
- Elminage Original (3DS eShop)
- Elmo's Letter Adventure (N64)
- Elmo's Number Journey (N64)
- ELO 1100 Chess (Switch eShop)
- Elrentaros Wanderings (Switch)
- Elsie (Switch eShop)
- Elta7 (Switch eShop)
- Elusive People (Switch eShop)
- Elva the Eco Dragon (Switch eShop)
- Elves Christmas Hentai Puzzle (Switch eShop)
- Elves Fantasy Hentai Puzzle (Switch eShop)
- Elves: The Enchanted Magic Heart (Switch eShop)
- Elypse (Switch eShop)
- Ember (Switch eShop)
- Ember Knights (Switch eShop)
- Embers of Mirrim (Switch eShop)
- Emblem of Gundam (DS)
- Embr (Switch)
- Embraced By Autumn (Switch eShop)
- Embracelet (Switch eShop)
- Emergency Call - The Attack Squad (Switch eShop)
- Emergency Driver Simulator (Switch eShop)
- Emergency Heroes (Wii)
- Emergency HQ (Switch eShop)
- Emergency Room: Real Life Rescues (DS)
- Emily Archer and the Curse of Tutankhamun (Switch eShop)
- Emio - The Smiling Man: Famicom Detective Club (Switch)
- Emma at the Farm (DS)
- Emma in the Mountains (DS)
- Emma: Lost in Memories (Switch eShop)
- emoji Kart Racer (Switch eShop)
- emoji MUSIC (Switch eShop)
- Emojikara: A Clever Emoji Match Game (Wii U eShop)
- Empire Invasion (Switch eShop)
- Empire of Angels IV (Switch eShop)
- Empire of Sin (Switch)
- Empires Shall Fall (Switch eShop)
- Empty Shell (Switch eShop)
- EmyLiveShow: Dangers and Mysteries Tale (Switch eShop)
- EmyLiveShow: Hentai Puzzle Game (Switch eShop)
- Enchanted (DS)
- Enchanted in the Moonlight - Kiryu, Chikage & Yukinojo - (Switch eShop)
- Enchanted in the Moonlight - Miyabi, Kyoga & Samon - (Switch eShop)
- Enchanted Path (Switch eShop)
- Enchanted Portals (Switch eShop)
- Enchanting Mahjong Match (Switch eShop)
- Enclave HD (Switch eShop)
- Enclave: Shadows of Twilight (Wii)
- Encodya (Switch eShop)
- Encore Rally (Switch eShop)
- Encounters: Music Stories (Switch eShop)
- End of Lines (Switch eShop)
- Ender Lilies: Quietus of the Knights (Switch eShop)
- ENDER MAGNOLIA: Bloom in the Mist (Switch eShop)
- Endless Deaths (Switch eShop)
- Endless Dungeon (Switch eShop)
- Endless Fables: Dark Moor (Switch eShop)
- Endless Fables: Shadow Within (Switch eShop)
- Endless Golf (Wii U eShop)
- Endless Memories (Switch eShop)
- Endless Ocean (Wii)
- Endless Ocean 2: Adventures of the Deep (Wii)
- Endless Ocean: Luminous (Switch)
- Endless Puzzle Fun Collection (Switch eShop)
- Endling - Extinction Is Forever (Switch eShop)
- Endocrisis (Switch eShop)
- Endurance - space action (Switch eShop)
- Enduring Mountain (Switch eShop)
- Enduro Racer (SMS)
- Ener-G Dance Squad (DS)
- Ener-G Gym Rockets (DS)
- Ener-G Horse Riders (DS)
- Energy Balance (Switch eShop)
- Energy Cycle (Switch eShop)
- Energy Cycle Edge (Switch eShop)
- Energy Invasion (Switch eShop)
- Energy Lab (Switch eShop)
- English Sensei: Teaching in Japan (Switch eShop)
- English Tracing Book (Switch eShop)
- English Training (DS)
- Enigmatis 2: The Mists of Ravenwood (Switch eShop)
- Enigmatis 3: The Shadow of Karkhala (Switch eShop)
- Enigmatis: The Ghosts of Maple Creek (Switch eShop)
- Enjoy the Diner (Switch eShop)
- Enjoy Your Massage! (WiiWare)
- Enoh (Switch eShop)
- Enraged Red Ogre (Switch eShop)
- Enter Digiton: Heart of Corruption (Switch eShop)
- Enter the Gungeon (Switch eShop)
- Enter the Gungeon 2 (Switch 2)
- Enter the Matrix (GCN)
- Enter x Exit the Gungeon (Switch eShop)
- Ephemeral -Fantasy On Dark- (Switch eShop)
- Epic Astro Story (Switch eShop)
- Epic Chef (Switch eShop)
- Epic Clicker Journey (Switch eShop)
- Epic Dumpster Bear (Wii U eShop)
- Epic Dumpster Bear 1.5 DX: Dumpster Fire Rebirth (Switch eShop)
- Epic Dumpster Bear 2: He Who Bears Wins (Switch eShop)
- Epic Loon (Switch eShop)
- Epic Word Search Collection (3DS eShop)
- Epic Word Search Collection (Switch eShop)
- Epic Word Search Collection 2 (3DS eShop)
- Epic Word Search Collection 2 (Switch eShop)
- Epic Word Search Holiday Special (3DS eShop)
- Epistory - Typing Chronicles (Switch eShop)
- Epitaph (Switch eShop)
- Epopeia Bundle - Coop Puzzles (Switch eShop)
- Epyx Rogue (Switch eShop)
- EQI (Switch eShop)
- EQQO (Switch eShop)
- Equestrian Training (DS)
- Equestrian Training (Switch eShop)
- Equilibrio (WiiWare)
- Equinox (SNES)
- Eragon (DS)
- Eraser VS Ruler (Switch eShop)
- Eroblast: Waifu Dating Sim (Switch eShop)
- Erogods: Asgard (Switch eShop)
- Erogods: Mirage (Switch eShop)
- Erogods: Olympus (Switch eShop)
- Erogods: Sunrise (Switch eShop)
- Erra: Exordium (Switch eShop)
- Escape - Backrooms Horror (Switch eShop)
- Escape 2088 (Switch eShop)
- Escape Academy: The Complete Edition (Switch eShop)
- Escape Doodland (Switch eShop)
- Escape Fear 2: Hide And Seek Horror (Switch eShop)
- Escape Fear: Hide And Seek Horror (Switch eShop)
- Escape First (Switch eShop)
- Escape First 2 (Switch eShop)
- Escape First 3 (Switch eShop)
- Escape First Alchemist (Switch eShop)
- Escape From a Deserted Island～The Adventures of Nyanzou&Kumakichi: Escape Game Series～ (Switch eShop)
- Escape from Chernobyl (Switch eShop)
- Escape from Ever Castle (Switch eShop)
- Escape From Flare Industries (Wii U eShop)
- Escape from Life Inc (Switch eShop)
- Escape from Mirrorland～The Adventures of Nyanzou&Kumakichi: Escape Game Series～ (Switch eShop)
- Escape From Mystwood Mansion (Switch eShop)
- Escape from Nightmare: Horror Tales (Switch eShop)
- Escape from Terror City (Switch eShop)
- Escape From Tethys (Switch eShop)
- Escape From The Island (Switch eShop)
- Escape from the Pharaoh's Tomb (Switch eShop)
- Escape from the Tower (Switch eShop)
- Escape from the Universe (Switch eShop)
- Escape From Zombie City (3DS eShop)
- Escape game & Card search game R01M (Switch eShop)
- Escape Game - FORT BOYARD 2022 (Switch eShop)
- Escape Game Fort Boyard (Switch eShop)
- Escape Game R00M (Switch eShop)
- Escape game R00M02 (Switch eShop)
- Escape game R00M03 (Switch eShop)
- Escape Game The Abandoned Hospital (Switch eShop)
- Escape Game The Deserted House (Switch eShop)
- Escape Game The Dr. Mouse's Lab (Switch eShop)
- Escape Game The House Under Rain (Switch eShop)
- Escape Game The Kitty School (Switch eShop)
- Escape Game The Old Folk House (Switch eShop)
- Escape Game The Painting Mansion (Switch eShop)
- Escape Game The Resort Facility (Switch eShop)
- Escape Game: Aloha (Switch eShop)
- Escape Goat (Switch eShop)
- Escape Lala - Retro Point and Click Adventure (Switch eShop)
- Escape Lala 2 - Retro Point and Click Adventure (Switch eShop)
- Escape Room Bundle Triple Pack (Switch eShop)
- Escape Room Killer: Moon, flowers and the Creepy Ghost (Switch eShop)
- Escape Room Pentalogy Bundle (Switch eShop)
- Escape Room Super Bundle (Switch eShop)
- Escape Room Ultimate Duo (Switch eShop)
- Escape Room Ultimate Trilogy (Switch eShop)
- Escape Rooms Bundle (Switch eShop)
- Escape Route (Switch eShop)
- Escape Site 13 (Switch eShop)
- Escape String (Switch eShop)
- Escape the Prison: 3 Days to Freedom (Switch eShop)
- Escape The Virus: Shoot 'Em Up! (DSiWare)
- Escape the Virus: Swarm Survival (DSiWare)
- Escape to the Ocean (Switch eShop)
- Escape Trick: 35 Fateful Enigmas (Switch eShop)
- Escape Trick: Convenience Store (DSiWare)
- Escape Trick: Ninja Castle (DSiWare)
- Escape Trick: The Secret of Rock City Prison (DSiWare)
- Escape! Zombie City (3DS eShop)
- Escapee GO! (DSiWare)
- escapeVektor (3DS eShop)
- escapeVektor: Chapter 1 (WiiWare)
- Escaping a Kid's Room～The Adventures of Nyanzou&Kumakichi: Escape Game Series～ (Switch eShop)
- Escaping a Fireworks Factory～Nyanzou&Kumakichi: Escape Game～ (Switch eShop)
- Eschatos (Switch eShop)
- ESP Ra.De. Psi (Switch)
- Espacio Cosmic Light-Seeker (Switch eShop)
- Espgaluda II (Switch eShop)
- ESPN International Track & Field (GBC)
- ESPN International Winter Sports 2002 (GCN)
- ESPN MLS ExtraTime 2002 (GCN)
- ESPN National Hockey Night (GBC)
- ESPN Sports Connection (Wii U)
- ESport Manager (Switch eShop)
- eSports Legend (Switch eShop)
- Esports Life Tycoon (Switch eShop)
- Essential Sudoku (DS)
- Estiman (Switch eShop)
- Estranged: The Departure (Switch eShop)
- ESWAT: City Under Siege (MD)
- ET Varginha (Switch eShop)
- Eternal Card Game (Switch eShop)
- Eternal Champions (MD)
- Eternal Darkness: Sanity's Requiem (GCN)
- Eternal Edge (Switch eShop)
- Eternal Hope (Switch eShop)
- Eternal Light (Switch eShop)
- Eternal Radiance (Switch eShop)
- Eternal Threads (Switch eShop)
- Eternights (Switch)
- Eternum Ex (Switch eShop)
- Ethan: Meteor Hunter (Switch eShop)
- Etherborn (Switch eShop)
- Etrian Mystery Dungeon (3DS)
- Etrian Mystery Dungeon 2 (3DS)
- Etrian Odyssey (DS)
- Etrian Odyssey 2 Untold: The Fafnir Knight (3DS)
- Etrian Odyssey HD (Switch eShop)
- Etrian Odyssey II HD (Switch eShop)
- Etrian Odyssey II: Heroes of Lagaard (DS)
- Etrian Odyssey III HD (Switch eShop)
- Etrian Odyssey III: The Drowned City (DS)
- Etrian Odyssey IV: Legends of the Titan (3DS)
- Etrian Odyssey Nexus (3DS)
- Etrian Odyssey Origins Collection (Switch eShop)
- Etrian Odyssey Untold: The Millennium Girl (3DS)
- Etrian Odyssey V: Beyond the Myth (3DS)
- Eufloria HD (Switch eShop)
- Euphoria (Switch eShop)
- Euro Truck Driver Simulator (Switch eShop)
- Europa (Switch eShop)
- European Conqueror 3D (3DS eShop)
- European Conqueror X (Switch eShop)
- Evan's Remains (Switch eShop)
- Evasion From Hell (Switch eShop)
- Evasive Space (WiiWare)
- Evel Knievel (GBC)
- even if TEMPEST (Switch eShop)
- even if TEMPEST: Dawning Connections (Switch eShop)
- Even the Ocean (Switch eShop)
- Event Horizon (Switch eShop)
- Event Horizon: Space Defense (Switch eShop)
- Eventide 2: Sorcerer's Mirror (Switch eShop)
- Eventide 3: Legacy of Legends (Switch eShop)
- Eventide: Slavic Fable (Switch eShop)
- Ever 17 - The Out of Infinity (Switch eShop)
- Ever 17/Never 7 Double Pack (Switch eShop)
- Ever Forward (Switch)
- Ever Oasis (3DS)
- Everafter Falls (Switch eShop)
- Everdark Tower (Switch eShop)
- Everdeep Aurora (Switch eShop)
- Everdell (Switch eShop)
- Everdream Valley (Switch eShop)
- Evergate (Switch eShop)
- Everhood (Switch eShop)
- Everhood 2 (Switch eShop)
- Everlasting Flowers (Switch)
- Everspace - Stellar Edition (Switch eShop)
- Evertried (Switch eShop)
- Everybody 1-2-Switch! (Switch)
- Everybody's Golf Hot Shots (Switch eShop)
- Everybody's Home Run Derby (Switch eShop)
- Everybody's Home Run Rush (Switch eShop)
- Everybody, Hearts! (Switch eShop)
- Everyday Soccer (DSiWare)
- Everyday♪ Today's MENU for EMIYA Family (Switch eShop)
- Everything (Switch eShop)
- Evidence Destroyer (Switch eShop)
- Evil Dead: The Game (Switch)
- Evil Defenders (Switch eShop)
- Evil Diary (Switch eShop)
- Evil God Korone (Switch eShop)
- Evil Inside (Switch eShop)
- Evil Nun: The Broken Mask (Switch eShop)
- Evil Tonight (Switch eShop)
- Evil Wizard (Switch eShop)
- EvilUP (Switch eShop)
- Evofish (Wii U eShop)
- Evoland Legendary Edition (Switch eShop)
- Evolings (Switch eShop)
- Evolution Board Game (Switch eShop)
- Evolution Skateboarding (GCN)
- Evolution Snowboarding (GCN)
- Evolution Worlds (GCN)
- EvoMon (Switch eShop)
- Ex Oblivione (Wii U eShop)
- Excave (3DS eShop)
- Excave II : Wizard of the Underworld (3DS eShop)
- Excave III : Tower of Destiny (3DS eShop)
- Exception (Switch eShop)
- Excessive Trim (Switch eShop)
- Excite League (Arcade)
- Excite Truck (Wii)
- Excitebike (NES)
- Excitebike 64 (N64)
- Excitebike: World Rally (WiiWare)
- Excitebots: Trick Racing (Wii)
- Exed Exes (Arcade)
- Exed Exes (VC Arcade)
- Exertainment Mountain Bike Rally / Speed Racer (SNES)
- Exertus: Redux (Switch eShop)
- Exhaust Heat (SNES)
- Exhausted Man (Switch eShop)
- Exile's End (Wii U eShop)
- Exiled (Switch eShop)
- Exit (DS)
- Exit Slum 11 (Switch eShop)
- Exit Station 7 (Switch eShop)
- Exit the Gungeon (Switch eShop)
- Exitman Deluxe (Switch eShop)
- Exocide (Switch)
- Exodemon (Switch eShop)
- Exodus (Switch eShop)
- Exographer (Switch eShop)
- Exophobia (Switch eShop)
- Exorder (Switch eShop)
- Expeditions: A MudRunner Game (Switch)
- Expelled! (Switch eShop)
- Exploding Kittens (Switch eShop)
- Explody Bomb (Wii U eShop)
- Exploration Adventures (Switch eShop)
- Explore Another World Bundle (Switch eShop)
- Explosionade DX (Switch eShop)
- Explosive Candy World (Switch eShop)
- Explosive Dinosaurs (Switch eShop)
- Explosive Jake (Switch eShop)
- Express Courier Pro: Urban Bike Delivery Simulator 2024! (Switch eShop)
- Extinction Eclipse (Switch eShop)
- Extra Bases (GB)
- Extra Coin (Switch eShop)
- Extreme Bike X (Switch eShop)
- Extreme Car Driver (Switch eShop)
- Extreme City Delivery: Bike Ride Simulator (Switch eShop)
- Extreme Exorcism (Wii U eShop)
- Extreme Ghostbusters (GBC)
- Extreme Ghostbusters: Code Ecto-1 (GBA)
- Extreme Hangman (DSiWare)
- Extreme Hangman 2 (DSiWare)
- Extreme Highway Racing: Real Speed Driver (Switch eShop)
- EXTREME POKER (Switch eShop)
- Extreme Race (Switch eShop)
- Extreme Skyway Racer Simulator (Switch eShop)
- Extreme Snowboard (Switch eShop)
- Extreme Speed Bundle Go! Fish Go! Adrenaline Rush, Jet Ski Rush (Switch eShop)
- Extreme Sports with the Berenstain Bears (GBC)
- Extreme Trucks Simulator (Switch eShop)
- Extreme-G (N64)
- Extreme-G 2 (N64)
- Extreme-G 3 (GCN)
- ExZeus: The Complete Collection (Switch eShop)
- Eye Exercise - Ver. kompeito (Switch eShop)
- Eyes: The Horror Game (Switch eShop)
- Eyeshield 21: MAX Devil Power (DS)
- Eyra: The Crow Maiden (Switch eShop)